This paper performs high-speed milling experiments on a typical wave-absorption honeycomb with crushed-tooth cutter under varied cutting parameters. The effects of cutting process on such parameters as cutting force, machined surface quality, cutting power, and cutting temperature are investigated. Then the optimized cutting parameters for high-speed milling of wave-absorption honeycomb are determined. The results indicate that the increase in cutting speed can help to decrease the cutting force and promote the machined surface quality. Meanwhile, the increase in feed speed, cutting depth, or cutting width causes the increase in specific material removal volume, which leads to higher cutting force and cutting temperature as well as severer machined surface defects. Taking the burr defects suppression as the main machining target and giving an overall consideration for the above other parameters, the optimized cutting parameters are recommended as the spindle speed of 16000 r·min^–1, feed speed of 4000 mm·min^–1, cutting depth of 10 mm, and cutting width of 15 mm. The research can provide guidances for selection of cutting parameters during high-speed milling of waveabsorption honeycombs.