Aiming at the high speed milling of the wing structure in the aviation field, a fixture design scheme with small interference, high flexibility, fast changing and high automation is proposed in this paper. The composition, principle and PLC control program of the fixture system is discussed in detail. In order to solve the problem that the waste of raw materials in the traditional folder and interference between machine tool and fixture in processing, adjustable positioning plate positioning, rotary clamping cylinder clamping, the use of sensor perception, PLC control achieve the electromagnetic valve orderly action and the workpiece reliable clamping in this paper. Correspondingly, the PLC control program is edited successfully. The fixture design can be used in the actual production of the aircraft structural components and the design of the automatic control fixture.