In order to meet the demands of company’s strategic planning and increased customer delivery quantity, the systematic layout planning (SLP) method was used to optimize the layout of tail cone production line. Firstly, the theory of systematic layout planning method was introduced, then the ramp up of tail cone production line was analyzed and calculated, including the calculation of production line balance ratio, identification of key bottleneck stations, and analysis of manning and key equipment required. Secondly, the position calculation and analysis of the jigs in tail cone production line were conducted by using the relationship chart, spatial relationship diagram to obtain various layout schemes of tail cone production line. Finally, according to the principles of lean production line layout, the above layout schemes were discussed and evaluated, then the optimum layout was determined by comprehensive evaluation.