Combined with the structural characteristics of large aircraft moveable airfoil, a set of whole process flexible automatic drilling scheme is designed. According to the machining way of the robot, a method of quick location by use the cup-and-cone system is proposed to realize the flexible drilling of robot. This paper also studied and built the process of automatic drilling and offline programming used for moveable airfoil. Changeable parameters drilling and breakout process are selected to drill the workpiece with different material, which improved the efficiency and quality of robotic drilling. It is proved that the flexible hole drilling scheme can meet the processing requirement of the product and improve the production efficiency.