As one of the critical steps of application of Automatic drilling and riveting technology, automatic drilling and riveting off-line programming will directly impact the manufacturing period of aircraft panel. This paper analyzed the process of automatic drilling and riveting off-line programming for aircraft panel. Aiming at improving the current situation, a method of fast automatic drilling and riveting off-line programming for aircraft panel is proposed, which has optimized off-line programming process and realizes batch processing for data of off-line programming based on CAA program development technology. It improves the efficiency and quality of automatic drilling and riveting off-line programming of the aircraft panel greatly based on this method.