The interference bushing hole reinforcement technology can significantly improve the mechanical properties and fatigue performance of the composite structural joint, and the interference size is the key process parameter of the technology. In this study, the resistance of interference bushing installation was analyzed theoretically, and the interference size of TA2 pure titanium interference bushing was taken as the research object. The strengthening resistance, the pore diameter change and the internal damage of the composite were studied by experiments. The results show that the interference size has a remarkable influence on the reinforcement resistance, and the reinforcement resistance increases obviously as the interference size increases. The interference size of the composite laminar hole is uneven along the mounting direction, as well as the amount of interference at the exit of the holes is higher than that at the entrance. When the interference size is 3%, the actual interference size at the exit of the composite laminate hole is as high as 1.5%, and the material damage occurs at the same time, so the interference size should be less than 3%.