The traditional positioning and clamping technology can’t meet the requirement of accurate, efficient and agile manufacturing for airplane pipes with various types, large quantity and complicated shapes. This paper focused on the digital and flexible positioning and clamping technology for airplane pipes. Three digital positioning methods for airplane pipes, including an array positioning jig, a passively reconfigurable jig and an actively reconfigurable jig, are proposed. The study offered a solution for digital positioning, clamping accurately and efficiently for pipes, to shorten preporing cycle for pipe manufacturing and reduce cost.