This paper presents a simulation prediction method of cutting force based on MATLAB in boring process, and a simulation software of cutting force is developed. By establishing the basic parameters of boring process, the relationship of cutting area and line length, cutting tool geometry parameters and machining process parameters is studied. According to the participation of the main and secondary cutting edges, the boring process is divided into four working conditions, and the cutting area and the line length are calculated respectively under the four working conditions, and the corresponding function curves are obtained by MATLAB simulation. The mathematical model of cutting force about cutting area and line length is established, and the relationship between cutting force and basic parameters of boring is obtained. At the same time, the vibration of cutting tools in boring process is studied. Through experimental comparison, the accuracy of simulation prediction method based on MATLAB is verified, which provids the basis for intelligent control of cutting force and vibration in boring process.