GH4169 superalloy is widely used in aero-engine hot components, and improving the fatigue resistance of GH4169 superalloy aero-engine blades is of great significance for the long-term stable service of aero-engines. Abrasive belt grinding is a finishing process of aero-engine blades, and the grinding parameters are closely related to the surface state and fatigue resistance after grinding. To reveal the effect of abrasive belt grinding process parameters on the fatigue resistance of the ground surface, this study carried out abrasive belt grinding on GH4169 superalloy fatigue samples with different process parameters and explored the influence of process parameters on surface integrity and fatigue life law. The results show that the line speed, feed speed, and downforce have significant effects on the surface roughness and residual stress of the GH4169 superalloy workpiece after grinding. When v=11 m/s, f =1000 mm/min, F=3 N, the fatigue resistance is the best. When the linear velocity is greater than 15 m/s and the downward pressure is greater than 6 N, the surface of GH4169 superalloy decreases, the depth of scratches increases, and the burning phenomenon is serious.