The ignition and diffusion combustion of TB12 flame-retardant titanium alloy were studied by friction test under simulated environment of aircraft engine compressor. The results showed that TB12 alloy could be burning under friction heat. The rotor and stator test piece could be ignited at the very beginning of friction, resulting in the size reduction of the test piece. However, because of the insensitivity to diffusion combustion of TB12 alloy, the combustion stop quickly, which is different from TC4 titanium alloy continuous diffusion combustion. The combustion products of TB12 alloy were possessed of good properties of strong adhesion, high strength, lubricating function and low thermal conductivity, thus making them adhesive to the surfaces of the test pieces, which reduced the fri ction heat and prevented the friction heat transition from surface to the matrix. According to the combustion characteristics of TB12 alloy, it can be designed for compressor stator blades. The TB12 blade could stop burning after initial combustion, and the combustion products will prevent friction between stator blades and rotor drum afterwards. The design and application of TB12 alloy in stator blades can reduce the risk of titanium fire failure caused by drum instability and friction between drum and stator blades.