The work aims to investigate the effect of Cr content of the coating on the microstructure and corrosion resistance of Fe60-xMn20Ni10Co10Crx (x=10, 12.5, 15, 20, 25, 30) high-entropy alloy coatings prepared by laser cladding technique on the Q345 steel substrate. The microstructure of the high-entropy alloy coating was analyzed by X-ray diffractometry and scanning electron microscopy. Meanwhile the microhardness and corrosion of the coating were characterized respectively by microhardness tester and electrochemical workstation. The results show that Cr10 coating consists only of BCC phase, and other coatings consist of BCC and FCC phases. With the increase of Cr content, the content of FCC phase first increases and then decreases. The microstructure changes from large equiaxed crystal to fine dendrites, and then changes to larger columnar crystals. At the same time, the hardness of the coatings also increased first and then decreased, reaching a maximum value (~500HV) when the Cr atomic fraction was 20%. Corrosion resistance tests in 3.5% NaCl solution showed that the Cr10 coating had the lowest corrosion current density and Cr12.5 had the highest corrosion potential. Therefore, laser cladding high-entropy alloy coating Cr20 has good comprehensive mechanics and corrosion resistance.