Ceramic particles reinforced aluminum alloy is a highly promising structural material with great potential for aeronautical applications due to the advantages of high stiffness, high strength and excellent fatigue property. This paper takes TiB₂ particle reinforced 2024 aluminum alloy material with a mass fraction of 5% as the research object, conducts material fatigue performance test research, and compares the influence of variables such as different material batches, material directions, plate thicknesses, and stress concentration factors on material fatigue performance. The results show that the influence of material batches, material directions and thickness on the fatigue performance is relatively small when the stress concentration factor is 1.0. The inclusion of TiB₂ particles increases the fatigue limit by 30%. When K_t = 3.1, thickness shows some effects on the fatigue limit. The results provide a research foundation for the application of TiB₂ reinforced aluminum alloy in aeronautical applications.