During the milling process of titanium alloy thin-walled parts, the cutter angle has a significant influence on the workpiece deformation, milling force and milling vibration. Extend the service life of cutting tools and reduce tool wear, milling process simulation model of Ti6Al4V titanium alloy thin-walled pieces is established by using ABAQUS software, with the milling force and milling temperature as evaluation index, using the single factor and orthogonal method to analyze the effects of cutting tool rake angle, relief angle and helix angle on the milling force and milling temperature, and the milling force experiment is carried out to verify the simulation results. The simulation results show that with the increase of the rake angle, the milling force decreases and the milling temperature fluctuates. With the increase of the relief angle, the milling force decreases, and the milling temperature decreases first and then increases. With the increase of helix angle, the maximum axial force increases, the maximum tangential force slowly decreases, the maximum radial force has no obvious variation, and milling temperature decreases first and then increases. Through orthogonal test and range analysis, the order of primary and secondary influence degree of different factors on indexes and the optimal level combination of factors are defined.