Aircraft skin parts are characterized with complex shape, large size, weak rigidity, difficult to machine and so on. Recently, the skin mirror milling technology appeared as a high precision green machining technology. Due to the weak rigidity of the skin blank, the gravity of the blank and the clamping force will cause deformation, which will result in the deviation between the actual surface and the design surface of the blank. To solve the above problem, an adaptive machining technology of aircraft large skin based on rapid scanning was proposed. The actual surface of the skin blank could be obtained quickly by laser scanning on machine, and then the machining program was transplanted based on a feature mapping method. The transplanted machining program has been successfully applied to practical production. The proposed adaptive machining technology solves the key problem of the skin mirror milling technology, can generate the machining program efficiently and satisfy the requirements of the form accuracy and thickness accuracy of the skin parts, and improve the production efficiency of the skin effectively, which will bring significant advancement to the mass production of domestic large aircraft.