There are a lot of difficulties in the process of CNC machining for open disk, such as small leading/trailing edge radius, difficult-to-machine materials, short tool life, complex CNC programming, long machining time, hard-tocontrol machining deformation, etc. The blisk grinding technique with CBN grinding wheels presented in this paper aims to solve the above-mentioned problems. To ensure this, firstly, cantilever grinding method and strip-width-maximization grinding method with barrel-shape grinding wheels are employed to realize high accuracy machining of blisk profile, the machining errors of suction/pressure surface are fluctuant in the range of 15~20μm, and the minimum leading/trailing edge radius is near 28.7μm. Secondly, a geometry-based adaptive machining method is suitable for the make up machining of leading/trailing edge, the residual error between machining area and its adjacent area is less than 10μm. Finally, 3-axis cylindrical CNC grinding method and cylindrical coordinate array grinding method are proposed and verified through simulation, which can shorten blisk (its blade length is less than 60 mm) machining time from hundreds of hours to 3 hours or so.