Beryllium–aluminum alloy is expected to become a key material for the lightweight of China’s new generation of aerospace equipment due to its excellent properties such as light weight, high specific stiffness and high specific strength. However, beryllium and aluminum have low solid solubility at room temperature and do not form intermetallic compound, resulting in poor interface bonding, which become the key to restrict improvement of the strength and plasticity of beryllium–aluminum alloy. In this paper, research status of the interface structure regulation of beryllium–aluminum alloys is reviewed, including the structural characteristics of the beryllium–aluminum interface, morphology of the beryllium phase, regulation of BeO, and alloying of the matrix. This paper focuses on the research progress of matrix alloying composition design to regulate the beryllium–aluminum interface structure, expecting to provide reference for the research on material composition design optimization and performance improvement of beryllium–aluminum alloys and other similar systems.