In order to explore the influence of processing parameters on delamination damage and control strategies in the drilling process of CFRP/Al interlayer structures, firstly, a test fixture is designed and a test platform is built. Different types and materials of drill bits are used to conduct drilling experiments on CFRP/Al interlayer structures, and high-quality drill bits are selected from them. Secondly, the optimal machining parameters were obtained through drilling and hole making experiments on high-quality drill bits under different process parameters. Finally, the variation of axial force and torque during the drilling process with process parameters was analyzed, and the hole making control strategy of CFRP/Al interlayer structure was analyzed. The research results show that the hard alloy double-edged step drill bit is the highest quality drill bit, with a speed greater than 4500 r/min and a feed time of 10 s as the optimal machining parameters, the maximum drilling axial force and torque decrease with the increase of feed time and speed, and the drilling quality of CFRP/Al interlayer structure can be improved by increasing the speed and feed time.