Two batches of powders with different levels of inclusion were prepared by the same hot isostatic pressing regime to produce FGH97 alloy, and the effect of the difference in the content of inclusion on the mechanical properties of FGH97 alloy was studied. The tensile properties of FGH97 alloys were tested, and the powder characteristics, alloy microstructure, and tensile fracture morphology were characterized. The results show that, the powder prepared by vacuum induction melting gas atomization (VIGA) method is denoted as powder, which has the characteristics of fine powder collection rate, small grain size of prepared alloy and easy to introduce inclusions. The abnormal particle inclusion of Sirich will lead to the formation of poor γ′ zone in alloy, affects the bonding between powders and reduces the plasticity of FGH97 alloy. At hot isostatic state, the FGH97 alloy has an elongation of 9.5% at room temperature and 1% at 650 ℃. FGH97 alloy was heat treated by solid solution + aging heat treatment, the poor γ′ zone in the matrix disappears, and the plasticity of FGH97 alloy is significantly improved, the room temperature elongation of FGH97 alloy is increased to 14.25%, the elongation at 650 ℃ is increased to 6%.