It is of great significance to study the influencing factors of the surface topography of nickel-based superalloy GH4169 processed by end-milling to control the surface roughness and improve the machining quality of GH4169. Based on single-factor end-milling experiments, the effects of milling speed, milling depth, feed per tooth and milling width on surface roughness and 3D surface topography were investigated. The results show that the influence degree on surface roughness is as follows: Feed per tooth, milling width, milling speed, milling depth, etc. The machined surface mostly presents the texture of vertical and horizontal phase, and the degree of influence on the surface texture depth is as follows: Milling speed, milling depth, feed per tooth, milling width; Combined with the processing surface roughness and 3D surface topography, the best processing parameters are: Milling speed V=100 m/min, milling depth t=0.1 mm, feed per tooth f_z=0.025 mm/z, milling width a_w=5 mm.