Ti₂AlNb pre-alloyed powders were prepared by plasma rotating electrode process (PREP) and electrode induction melting gas atomization (EIGA) respectively, and the pre-alloyed powders were characterized. Ti₂AlNb alloy was prepared by hot isostatic pressing (HIP) process, and the effects of powder preparing process on microstructure and mechanical properties of Ti₂AlNb alloy were investigated. The experimental results show that the compaction density of Ti₂AlNb powder prepared by EIGA method is higher than that of PREP method. The forming research of Ti₂AlNb impeller was carried out under the regime of 1030 ℃/140 MPa/3 h based on the powder metallurgy HIP near net shape technology. The finite element simulation results show that the higher the powder compaction density, the smaller the deformation degree of the HIPed component. Ti₂AlNb pre-alloyed powder prepared by EIGA with higher compaction density is preferred to prepare powder metallurgy complex components.