In the aerospace field, thin-walled structural parts are connected and assembled with extremely high precision, the holes for the connections therefore have high tolerance requirements. Due to its low stiffness, there is a great deal of deformation and vibration in the drilling process, which seriously affects the drilling precision and quality. Aiming at the problems of large clamping span, insufficiency and difficulty in effectively supporting the aircraft wing box and other components in the traditional clamping method, this paper proposes to improve the local stiffness during the drilling of thinwalled structural parts through the positive adsorption auxiliary support, which in turn improves the drilling quality of the thin-walled structural parts, and investigates the effect of positive adsorption auxiliary support on the drilling of the thinwalled structural parts through the combination of simulation and experiments. The results show that under the simulation and experimental conditions in this paper, the positive adsorption auxiliary support can improve the stiffness of the drilling position by more than 40 times, reduce the roughness of the hole wall by more than 67%, reduce the roundness tolerance by more than 60%, reduce the deviation of the hole entrance and exit diameters by more than 90%, and reduce the aperture deviation by more than 50%, so that the positive adsorption auxiliary support can significantly improve the precision and quality of the thin-walled structural parts.