Stack materials composed of carbon fiber reinforced polymer (CFRP) and titanium alloys are widely used in the aerospace field due to their excellent mechanical properties. In order to prolong the tool life, this paper adopted the center blowing, MQL (Minimum quantity lubrication), water-based coolant and liquid nitrogen cooling methods in the lowfrequency vibration assisted drilling experiment of CFRP/titanium alloy stacks to study the effects of these four cooling and lubrication methods on drilling temperature, axial force and tool wear. The results show that the machining temperature is the highest when center blowing is used, and temperature is the lowest when using liquid nitrogen; The thrust force is the largest when using liquid nitrogen, and is the smallest when water-based coolant is used; The tool life is the longest when using water-based coolant, reaching 66 holes, and the worst when using liquid nitrogen cooling, only 12 holes. The main forms of tool wear are adhesion wear and abrasive wear.