The harsh performance and requirements of near-space supersonic aircraft (NSSA) pose a serious challenge for the materials selection. Short-time heat-resistant titanium alloys with high temperature, low density, high specific strength, high specific stiffness, excellent manufacturing and processing forming properties has become the preferred material for the manufacturing of NSSA. Based on the performance and materials selection requirements of the NSSA, starting from the needs of practical engineering application in three aspects of properties, manufacturing cost and forming process, this article proposeds some thoughts and suggestions concerning usage of short-time heat-resistant titanium alloys in the structures of aircraft, which aims to provide references for the material selection, design and development of the structure of NSSA.