As a typical difficult-to-machine material, beryllium material is mainly processed by turning, but beryllium material is harder and more brittle, which often has local fractures and sharp edge chipping defects; Cutting force is an important factor that affects tool wear and processing quality, predicting the cutting force of turning beryllium materials is of great significance to the selection of cutting parameters. Based on the semi-empirical prediction formula of mechanical analysis, this paper establishes a thermal-mechanical coupling-based cutting force prediction model for beryllium turning, and conducted experimental verification. The result shows that the predicted value of the model fits well with the experimental value, and the overall error is 10.79%, the error range is 2.96% – 20.53%. The change mechanism of tool wear and surface roughness under different cutting parameters is analyzed, which provides a certain theoretical reference for beryllium turning processing.