The effects of solution aging heat treatment on the microstructure and mechanical properties of a new kind of Ti–Al–Mo–V–Cr–Zr series ultra-high strength titanium alloy were investigated. The results indicate that the microstructure of the raw material consists of equiaxed or short rod-shaped primary α phase and matrix β phase. After solution and aging treatment, the microstructure is composed of primary α phase and transformed β phase with a large number of secondary α phases dispersedly distributed. Otherwise, the aging temperature has a significant effect on its mechanical properties. With the increasing of aging time, the tensile strength and yield strength of the alloy decrease and the plasticity increases. Under the condition of aging treatment at 520 ℃ , the tensile strength is 1508 MPa, the yield strength is 1439 MPa, and the elongation is 7.6%, showing a relatively good match of strength and plasticity. At the same time, the room temperature smooth （Kt=1） axial high-cycle fatigue performance is good, and the median fatigue strength is 868 MPa, which can provide data support for promoting its engineering application.