Mechanical metamaterials (MMMs) have become a research hotspot in the application of aerospace, energy automobile, manufacturing, and military due to their light weight, high strength, and high energy absorption. Selective laser melting (SLM) additive manufacturing can produce complex microstructure with high precision and resolution, thus being suitable to fabricate complex MMMs. In this study, a design scheme of three-dimensional (3D) MMMs models based on a“ double V” configuration honeycomb topology was proposed, which were subsequently printed by SLM. Through the combination of theoretical calculation, simulation, and experiments, the influences of various structural parameters on the compression mechanical response of the “double V” configuration honeycomb MMMs were investigated. The findings provide an approach to manually tailor the negative Poisson's ratio of MMMs.