In order to reduce the defects in the joint area of Ti–6Al–4V titanium alloy laser-formed joints and improve the joint quality, orthogonal test method is used to optimize the process parameters. The comprehensive assessment indicators include tensile strength, yield strength, elongation and internal quality. And the influence degree of each process parameter is analyzed by mathematical statistics, which provides near-optimal process parameters for the study of mechanical properties of subsequent forming joints. The result shows that: when the line energy density is 0.5W · min/ mm², groove angle is 70°, scan path is +60°– –30°, we got the near-optimal evaluation result. And the linear energy density of each parameter has a significant effect on the tensile property of the joint specimens. The joints can meet the national standard when the optimized process parameters are used. The result shows that the method can provide a reference for reasonable selection of the joint forming process parameters and ensure the quality.