In order to fabricate a type of titanium hollow structure, a new process is developed based on hot isostatic pressing (HIP). The hollow ring structure is first decomposed into the skin plus ribs structure, then these substructures are combined together with adding a internal package into the hollow space. After HIP process, rectangular, cylindrical and conical hollow structures are fabricated, under 800-900℃ /100-200MPa/1-3h. The quality of this part is analyzed through profile examination, interface microstructure analysis and mechanical performance test. The results show that the interfacial diffusion bonding ratio of hollow structures almost reaches 100%, and the highest bonding strength reaches more than 980MPa, which is equal to the base metal. The fracture profile of diffusion bonding interface tensile samples shows ductile properties, and the feasibility of this new process is verified, which will provide reference for aerospace applications.