In the trend of organizational change from static centralized hierarchy to dynamic distributed network structure, the manufacturing system presents new features such as dynamic, complex and autonomous. As a new method to solve the problem of complex, dynamic and distributed artificial intelligence applications, Agent technology has been widely used in intelligent manufacturing and digital workshop. The goal of intelligent manufacturing and digital workshop is both to achieve the interaction and integration of physical space and information space. Around the goal and the new features of the manufacturing system, firstly, the virtual-real synthesis manufacturing system is introduced briefly. Then the application and research status of Agent-based modeling, simulation and supervisory control of manufacturing system are summarized. Finally, the development trend of Agent-based manufacturing system modeling and simulation is prospected.