With the deep application of new generation information technology in industry, traditional product research and development mode has changed. This paper introduces the modeling and simulation, dynamically predicts and estimates complex product lifecycle business process by using digital clues and digital twin, to achieve the business closedloop mapping of digital space and physical space of the product planning and definition, simulation and analysis, verification and confirmation. At last, combined with the smart manufacturing framework of aviation industry, the application idea in the production lifecycle is given to enhance the digital and intelligent level of the production process.