Surface roughness for TB6 titanium alloy impacts its performance significantly, The effect on surface roughness and defects was studied through face milling parameters, dry milling and tool wear experiment. The results show that surface roughness for TB6 titanium alloy is mostly sensitive to the variation of feed per tooth, the next is the milling width, then is the depth of milling and the last is the milling speed. The VB have a significant influence on surface roughness, especially when VB is greater than 0.2mm, the roughness values increases significantly as well as bringing on some scratches and grooves. Feed mark, smeared and uplift material defects are observed on all machined surface samples. A large number of deposited material or pitting corrosion adhere to the worked surface during dry milling as well as burr formation increasing. Burr formation decreases with the increasing of milling speeds, while increases with the VB increasing. Wherefore, TB6 titanium alloy is suitable for low milling speed with cooling lubrication during milling.