The one-side pressed hole making process is a key technology for light automated holing system of aircraft. This article selects the typical position of the docking between aircraft fuselage and head section of a certain model as the research object, and mainly studies the influence of arrangement of the pre-tightening fixture on the quality of the hole during the unidirectional compression. Firstly, a simulation model was established to determine the influence parameters. On this basis, the simulation experiment was performed to obtain the discrete sample point data. Finally, the response surface methodology approximation model was established through Isight platform and an adaptive simulated annealing algorithm was used to analyze and optimize discrete data. Optimization results obtain the optimal pre-tightening arrangement parameters and corresponding layout scheme.