To meet the production mode of small batch, multiple forms and large structure in the field of aviation anufacturing, a flexible robot gluing system based on point cloud analysis is designed. Firstly, the composition, process nd interaction mode of components of the gluing system are discussed. Then the coordinate system calibration of the luing system is introduced. The pose matrix of the robot coordinate system and the laser tracker coordinate system is reatively fitted based on the feature structure recognition, forming a combined gluing system. Finally, the point cloud nalysis of the gluing system is introduced, first, the intersection line between the skin and stringer is obtained based on he point cloud feature extraction, second, the robot gluing trajectory information is constructed based on the principal urve theory and B-spline curve fitting. The robot gluing system constructed in this way makes full use of the point cloud ata and its structural characteristics without manual teaching or off-line programming. After generating the gluing control rogram, only the simulation is needed to verify the correctness of the program, which greatly simplifies the operation teps, realizes the flexible robot gluing system, and meets the requirements of the aviation manufacturing field for the obot gluing system.