As one of the key performances of infrared guidance devices, it’s of great significance to carry out innovative research on the intelligent design method of environmental adaptability. The development and present situation of MBSE and AI are briefly introduced. The intelligent design method is analyzed and five models are established by SysML, such as one intelligent design system architecture model with five levels, one reasoning process model consisting of several intelligent algorithms, one object-oriented structure model of knowledge and one activity model for extracting knowledge form the cases database using FNN approach. A useful reference for I2CAD system of precise guiding devices is provided by the research.