The blisk consists of a number of blades arranged in a circular array on the hub. Because the blade is a weakly rigid part, tool wear, chatter and tool deformation are serious during finishing, which affect the further improvement of machining quality. A new combine machining technology of milling and grinding for full surface finishing was proposed. The blade is processed by grinding, while the blade root and flow path are processed by milling. The full surface machining was realized by controlling the joint error in the overlap area of grinding and milling tool rails. The experimental results show that the combined machining technology shows good machining quality, the tool connecting error is controlled within 0.01 mm, and the overall blade profile error is less than 0.04 mm. The feasibility of the multi-spindle array machining of the blisk is verified by the double spindle machining experiment, which can greatly improve the machining efficiency while ensuring the machining quality.