Carbon fiber reinforced polymer (CFRP) is widely used in aerospace and automotive lightweight manufacturing due to its lightweight, high strength and corrosion resistance. However, there are still some problems in the processing of CFRP, such as edge burrs, interlaminar tearing and so on. Many new processing schemes for CFRP materials are proposed in the industry. As an important processing method, the laser processing has become one of the research hotspots. The hole cutting process of carbon fiber composite plate was studied by using 532nm picosecond laser. The effects of laser rotary cutting, parallel filling cutting and cross filling cutting on machining quality were compared. The quality of the hole and the range of heat affected zone were observed by the confocal microscope. The experimental results showed that the scanning method of laser rotary cutting has the highest removal efficiency, the smallest tapers, and the hot affected zone was small. At the same time, D5766 open-hole tensile standard was adopted to conduct tensile experiments on three kinds of laser scanning hole making samples and mechanical hole making sample, and the results were analyzed. This research would provide new research ideas for high quality processing of CFRP.