It is believed that wing assembly is of great importance in aircraft manufacturing. With the change of market demands, such as the number of holes of wing box assembly, the requirements of high quality and high work intensity, various digital and automatic equipment appeared being popular both in international and domestic aviation manufacturing industry. Because of the high flexibility, robots are widely applied to implement digital drilling operation assembly of the wing skin panels, which leads a new trend in wing assembly of the modern aircraft. This paper introduced a mobile digitized drilling system for wing assembly based on AGV carrying robot. Besides, the author explored the integration technology of compound robot drilling system. The integration of the whole system was achieved through the mechanical structure integration, electrical control integration and software control integration, which could be the key point in achieving automatic and accurate drilling of the large aircraft wing box robot system.