The creep deformation behavior of 2219T87 aluminum alloy under different stress states is studied through creep experiments. The results show that the total creep strain of 2219T87 aluminum alloy increases with the increase of stress, and the total creep strain in tensile state is higher than that in compressive state. Under the tensile stress of 300 MPa, the total creep strain after 300 h reaches 0.634%, which is 72.3% higher than that under the stress of 200 MPa and 13.6% higher than that under compression. The observation of microstructure shows that the precipitated phases in the original state are dot-like and reticulate, and evenly distributed on the aluminum alloy matrix. After creep, the number of precipitated phases decreased obviously. TEM observation and XRD calculation verified the occurrence of redissolution of precipitated phases. The calculated creep stress index is 3.17, which proves that the creep mechanism is controlled by grain boundary sliding.