Based on the dual five axis linkage automatic drilling and riveting equipment, combined with the structural characteristics and sealing requirements of the aircraft seam sealing components, research on burr free automatic hole making and interference fit riveting technology was carried out. Through the development of drilling countersinking integrated tool, the test of automatic drilling technology parameters and the design of pre-connection technology, we have achieved breakthroughs in the processing of sealed metal laminated materials with burr-free drilling (burr height less than 0.13 mm) within the seam, achieving hole diameter accuracy better than H9. The deviation angle between the normal line of the curved surface where the hole is located before processing and the axis of the hole after processing is less than 0.3°, hole surface roughness reached Ra1.6 μm, ensuring high-precision hole making quality. In response to the requirements for long life and fatigue of the aircraft, experimental research was conducted on the influencing factors of riveting interference, and the influence trend of interference magnitude on fatigue life was analyzed. The optimal control range of interference and influencing factors under fatigue life was obtained, which meets the strict requirements for the overall sealing and fatigue life of the aircraft in the unique combat service environment of high salinity, high humidity and high temperature.