Abstract：The fusion design method based on multi-lattice is expected to bring a new approach to weight reduction and increase performance of aerial structures. The existing design methods of multi-lattice structure have some problems, such as very small rod diameter, topology discontinuity and weak bearing capacity. An optimal design strategy of multi-lattice transition interface based on substructure parameter regulation was proposed. By adjusting the connectivity of transition region of different lattice configurations, the geometric high-order continuous optimization of multi-lattice transition boundary was realized. On this basis, the inflfluence of difffferent arrangement modes on deformation behavior and load-bearing capacity of multi-lattice structure was further analyzed, and the theoretical prediction model of geometric parameters-performance of multi-lattice structure was established. Experimental results show that compared with the traditional multi-lattice design method, the structural strength of the proposed method is improved by 52.2%. In addition, reasonable interface morphology can effffectively transfer load and avoid catastrophic failure of the structure at the interface.