Abstract：The aero-engine pulse final assembly line (PFAL) has the characteristics of complex main equipment, high construction and operation cost. The single station module is the basic unit of PFAL, which undertakes the tasks of pulsating transportation, clamping and fixing, large parts docking and parts installation, therefore, it is difficult to plan the process flow and design the equipment motion program. The integrated simulation of PFAL can verify the structure and mechanism design, workflow design and motion control design of single-module, which is of great significance for typical module development. In this paper, a typical module integrated simulation with man-in-loop scheme based on digital twin model and actual control signal is proposed. Based on this scheme, the domestic simulation software and integrated simulation platform with complete intellectual property rights are developed, and the evaluation of a certain type of aircraft generator pulse assembly process is completed. The results show that the developed platform can be used to evaluate the new pulsation assembly process of aero-engine, and can support the scheme validation and operation training of man-in-the loop.