Titanium alloy blisk is a typical lightweight and efficient part of advanced aero-engine compressor. While working, the blade and disk of blisk are subjected to quiet different thermal and loading condition, it is an effective mean to improve the weight reduction effect of compressor rotor and to meet more stringent and variable thermodynamic condition through dual-property design instead of the traditional uniform-property design. The feasibility of two gradient heat treatment processes (GHTP), that is, separated-region temperature-controlled GHTP and partial-packed time-controlled GHTP, for manufacturing titanium alloy dual-property blisk is compared, and the microstructural controllability of blade, disk and transition zone is evaluated. The results show that the two processes can form stable and controllable temperature gradient in the transition zone of blisk, and dual microstructure is formed, that is, blade with duplex structure, disk with fine lamellar structure, the area and size of the transition zone is controllable, and the microstructure is gradually changed as well. According to the general contour characteristic, microstructure and performance requirements of the blisk forging, the suitable manufacturing process and corresponding process parameters are applied.